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High-intensity interval training (HIIT) effectively enhances heart function via miR-195 dependent cardiomyopathy reduction in high-fat high-fructose diet-induced diabetic rats.

Authors
  • Khakdan, Soheyla1
  • Delfan, Maryam2
  • Heydarpour Meymeh, Maryam3
  • Kazerouni, Faranak1
  • Ghaedi, Hamid4
  • Shanaki, Mehrnoosh1
  • Kalaki-Jouybari, Fatemeh1
  • Gorgani-Firuzjaee, Sattar5
  • Rahimipour, Ali1
  • 1 Department of Medical Laboratory Sciences, School of Allied Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , (Iran)
  • 2 Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Alzahra University, Tehran, Iran. , (Iran)
  • 3 Department of English Language, School of Allied Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , (Iran)
  • 4 Department of Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , (Iran)
  • 5 Department of Medical Laboratory Sciences, School of Allied Health Medicine, AJA University of Medical Sciences, Tehran, Iran. , (Iran)
Type
Published Article
Journal
Archives of physiology and biochemistry
Publication Date
Jul 01, 2020
Volume
126
Issue
3
Pages
250–257
Identifiers
DOI: 10.1080/13813455.2018.1511599
PMID: 30320520
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Aims: Regarding the fact that up-regulation of miR-195 in diabetic hearts has a potential role in diabetic cardiomyopathy, the present study investigated whether continuous endurance training (CET) and high-intensity interval training (HIIT) reduces miR-195 expression and which exercise is effective in this regard.Methods: Diabetes was induced by high-fat high-fructose diet (HFHFD). Then, the rats were sub-divided into three categories; sedentary (HFHFD + SED), continuous endurance training (HFHFD + CET), and high-intensity interval training group (HFHFD + HIIT). After eight weeks of running, expression of miR-195 and myocardial function were evaluated.Results: HIIT effectively decreases the expression of miR-195 and increases the expression of Sirt1 and BCL-2 in diabetic rats compared with CET. Our results showed that HIIT compared with CET increases left ventricular ejection fraction (LVEF%) and fractional shortening (FS%).Conclusions: Our results indicated that exercise, especially HIIT is an appropriate strategy for reducing miR-195 and improving myocardial function in diabetic rats compared with CET.

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