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Higher expression of glucocorticoid receptor in peripheral mononuclear cells in inflammatory bowel disease.

Authors
  • Schottelius, A
  • Wedel, S
  • Weltrich, R
  • Rohde, W
  • Buttgereit, F
  • Schreiber, S
  • Lochs, H
Type
Published Article
Journal
The American journal of gastroenterology
Publication Date
Aug 01, 2000
Volume
95
Issue
8
Pages
1994–1999
Identifiers
PMID: 10950048
Source
Medline
License
Unknown

Abstract

Our data show a systemic increase in GR expression and a decrease in the affinity to the GR in IBD, in contrast to other inflammatory diseases such as rheumatoid arthritis and asthma. These changes point towards a systemic character of IBD, which might be considered in a decision between topical and systemic treatment.

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