Affordable Access

deepdyve-link
Publisher Website

Higher estradiol levels are associated with lower neonatal birthweight after fresh and frozen embryo transfers. A cohort study of 3631 singleton IVF pregnancies.

Authors
  • Tarlatzi, Theoni1
  • Venetis, Christos2, 3
  • Sassi, Asma1
  • Devreker, Fabienne1
  • Englert, Yvon1
  • Delbaere, Anne1
  • 1 Hôpital Erasme - ULB, Fertility Clinic, Department of Obstetrics and Gynecology, Brussels, Belgium. , (Belgium)
  • 2 Centre for Big Data Research in Health, University of New South Wales, Sydney, NSW, Australia. , (Australia)
  • 3 School of Women's and Children's Health, University of New South Wales, Sydney, NSW, Australia. , (Australia)
Type
Published Article
Journal
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
Publication Date
Jul 01, 2021
Volume
37
Issue
7
Pages
618–623
Identifiers
DOI: 10.1080/09513590.2020.1827383
PMID: 33016794
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To assess the birthweight of neonates conceived after fresh and frozen embryo transfers (FET) and, if different, to investigate whether estradiol levels during the late follicular phase were associated with the observed difference. Singleton pregnancies from fresh and FET transfers between January 1990 and December 2013 were compared retrospectively. A total of 2885 singleton pregnancies after fresh embryo transfer and 746 after FET were analyzed. Obstetric and neonatal outcomes were compared between fresh and FET cycles. The singletons born after FET were found to have a significantly higher birth weight (3313 g), compared to those born after fresh embryo transfer (3143 g); p < .001. The main predictor of this difference was found to be estradiol levels at the end of the follicular phase. The difference in birthweight was inversely correlated to estradiol levels considering all cycles together but also considering fresh and frozen cycles separately. Our study demonstrates a link between high estradiol levels and low birth weight of singletons after IVF both in fresh and frozen-thawed embryo transfer cycles. It provides additional support to the involvement of hyperestrogenemia in the process of implantation and on the subsequent fetal development.

Report this publication

Statistics

Seen <100 times