Affordable Access

High-titer, low-avidity (HTLA) antibodies and antigens: a review.

Authors
  • Rolih, S D
Type
Published Article
Journal
Transfusion medicine reviews
Publication Date
Apr 01, 1989
Volume
3
Issue
2
Pages
128–139
Identifiers
PMID: 2520549
Source
Medline
License
Unknown

Abstract

Antibodies that react to HTLA characteristics cause difficulties in serologic testing because of the weak reactions they produce in the indirect antiglobulin test. Those specificities that are more frequently encountered (anti-Yka, -McCa, -Kna, -Ch) are directed toward antigens of high incidence in both the white and black populations. They have not been shown to cause significant destruction of transfused antigen-positive red cells. The antibodies create problems in serologic tests because the reactions they produce interfere with the identification of reactions due to other, clinically significant antibodies.

Report this publication

Statistics

Seen <100 times