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A high-throughput three-capillary noise-cancelling viscometer for chromatographic systems.

Authors
  • Yau, Wallace W
  • Cong, Rongjuan
  • Gillespie, David
Type
Published Article
Journal
Analytical and Bioanalytical Chemistry
Publisher
Springer-Verlag
Publication Date
Feb 01, 2011
Volume
399
Issue
4
Pages
1563–1570
Identifiers
DOI: 10.1007/s00216-010-4182-x
PMID: 20865409
Source
Medline
License
Unknown

Abstract

This paper describes an analytical three-capillary viscometer detector that eliminates the traditional viscometer "hold-up" volume (commonly found in four-capillary designs) while maintaining cancellation of short-term pump noise and long-term baseline drift of temperature and solvent flow rate that are inherent in chromatography systems. This improvement allows a staggered sample injection approach in chromatography, yielding a significant increase in sample throughput by cutting down the chromatographic run time. It also provides a more robust design as it does not require capillary rebalancing, complex purging, flushing or changing the hold-up volume to accommodate long-term chromatographic use.

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