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High-throughput proteomics using Fourier transform ion cyclotron resonance mass spectrometry.

Authors
  • Qian, Wei-Jun
  • Camp, David G 2nd
  • Smith, Richard D
Type
Published Article
Journal
Expert Review of Proteomics
Publisher
Informa UK (Taylor & Francis)
Publication Date
Jun 01, 2004
Volume
1
Issue
1
Pages
87–95
Identifiers
PMID: 15966802
Source
Medline
License
Unknown

Abstract

The advent of high-throughput proteomic technologies for global detection and quantitation of proteins creates new opportunities and challenges for those seeking to gain greater understanding of the cellular machinery. Here, recent advances in high-resolution capillary liquid chromatography coupled to Fourier transform ion cyclotron resonance mass spectrometry are reviewed along with its potential application to high-throughput proteomics. These technological advances combined with quantitative stable isotope labeling methodologies provide powerful tools for expanding our understanding of biology at the system level.

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