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High-throughput mutation profiling in intraductal papillary mucinous neoplasm (IPMN).

Authors
  • Lubezky, Nir
  • Ben-Haim, Menahem
  • Marmor, Sylvia
  • Brazowsky, Eli
  • Rechavi, Gideon
  • Klausner, Joseph M
  • Cohen, Yoram
Type
Published Article
Journal
Journal of Gastrointestinal Surgery
Publisher
Springer-Verlag
Publication Date
Mar 01, 2011
Volume
15
Issue
3
Pages
503–511
Identifiers
DOI: 10.1007/s11605-010-1411-8
PMID: 21225475
Source
Medline
License
Unknown

Abstract

Of the 22 screened tumor-related genes, only K-ras, p53, and PIK3CA mutations were found in IPMN. K-ras mutations are more prevalent in invasive than premalignant IPMN. The variable coexistence of mutations in the invasive cancer and in the adjacent precursor cells may point to the heterogeneous nature of this tumor.

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