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High sensitivity of gastric mucosa to ulcerogenic effect of indomethacin in rats with diabetes.

Authors
  • Podvigina, T T
  • Bagaeva, T R
  • Bobryshev, P Yu
  • Filaretova, L P
Type
Published Article
Journal
Bulletin of experimental biology and medicine
Publication Date
Nov 01, 2011
Volume
152
Issue
1
Pages
43–46
Identifiers
PMID: 22803036
Source
Medline
License
Unknown

Abstract

One week after injection of streptozotocin (60 mg/kg intravenously), rats developed diabetes associated with a significant increase of gastric mucosa sensitivity to the ulcerogenic effect of indomethacin (35 mg/kg subcutaneously). Since potentiation of the ulcerogenic effect of indomethacin was observed only in rats subjected to fasting before drug injection, we hypothesize that this effect was caused by a drop of high glucose level in the blood after fasting.

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