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High-resolution MRI of uveal melanoma using a microcoil phased array at 7 T.

Authors
  • Beenakker, J W M
  • van Rijn, G A
  • Luyten, G P M
  • Webb, A G
Type
Published Article
Journal
NMR in Biomedicine
Publisher
Wiley (John Wiley & Sons)
Publication Date
Dec 01, 2013
Volume
26
Issue
12
Pages
1864–1869
Identifiers
DOI: 10.1002/nbm.3041
PMID: 24123279
Source
Medline
Keywords
License
Unknown

Abstract

High-field MRI is a promising technique for the characterisation of ocular tumours, both in vivo and after enucleation. For in vivo imaging at 7 T, a dedicated three-element microcoil array was constructed as a high-sensitivity receive-only device. Using a dedicated blink/fixation protocol, high-resolution in vivo images could be acquired within 3 min in volunteers and patients with no requirement for post-acquisition image registration. Quantitative measures of axial length, aqueous depth and lens thickness in a healthy volunteer were found to agree well with standard ocular biometric techniques. In a patient with uveal melanoma, in vivo MRI gave excellent tumour/aqueous body contrast. Ex vivo imaging of the enucleated eye showed significant heterogeneity within the tumour.

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