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[High pressure liquid-liquid chromatography: correlation between retention times and biological activity of 1,3,5-triazine derivatives].

Authors
  • Vitali, T
  • Gaetani, E
  • Laureri, C F
  • Branca, C
Type
Published Article
Journal
Il Farmaco; edizione scientifica
Publication Date
Jan 01, 1976
Volume
31
Issue
1
Pages
58–65
Identifiers
PMID: 939320
Source
Medline
License
Unknown

Abstract

An investigation has been made of the possibility of using the retention times t obtained by reversed phase high pressure liquid-liquid chromatography in the study of quantitative structure-activity relatiionships. Taking as an example a group of herbicides which inhibit the Hill reaction, it was found that log t is additive and can be used as the hydrophobic parameter in regression analyses. The characteristics, advantages and possible developments of the method are discussed and the analytical interest is highlighted.

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