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High pressure liquid chromatographic assay for mexiletine in serum.

Authors
  • Grech-Bélanger, O
  • Turgeon, J
  • Gilbert, M
Type
Published Article
Journal
Journal of chromatographic science
Publication Date
Nov 01, 1984
Volume
22
Issue
11
Pages
490–492
Identifiers
PMID: 6501531
Source
Medline
License
Unknown

Abstract

A highly sensitive, rapid, and specific high pressure liquid chromatographic assay for the analysis of the antiarrhythmic agent mexiletine is reported. The method involves extraction of mexiletine with organic solvent followed by analysis using fluorescence detection. The minimum measurable limit is 1 ng and inter- and intra-day coefficients of variation are less than 5.8%. The method is useful for pharmacokinetic studies and routine serum monitoring of mexiletine.

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