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High-pressure, compact, modular radiosynthesizer for production of positron emitting biomarkers.

Authors
  • B, Amaraesekera
  • Pd, Marchis
  • Kp, Bobinski
  • Cg, Radu
  • J, Czernin
  • Jr, Barrio
  • R, Michael Van Dam
Type
Published Article
Journal
Applied Radiation and Isotopes
Publisher
Elsevier
Volume
78
Pages
88–101
Identifiers
DOI: 10.1016/j.apradiso.2013.04.024
Source
van Dam Lab
License
Unknown

Abstract

A robust, modular, semi-automated synthesis unit useful for conducting radiochemical reactions under pressurized conditions (up to ∼200psi [1.4MPa]) for the production of PET biomarkers has been developed. This compact unit (7.6cm×33.0cm×58.4cm) is capable of performing any single step reaction that is generally encountered in radiochemical syntheses, and multiple units can be combined for more complex syntheses. The versatility of a 3-unit system is exemplified by reliably conducting the multi-step syntheses of 2 -deoxy-2 -[(18)F]fluoro-1-β-arabinofuranosyl-uracil and -cytosine derivatives, which involve corrosive and moisture sensitive reagents under pressurized conditions.

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