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High plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgery

Authors
  • La Sala, Lucia1
  • Tagliabue, Elena2
  • Vieira, Elaine3
  • Pontiroli, Antonio E4
  • Folli, Franco4, 5
  • 1 IRCCS MultiMedica, Milan, 20138, Italy , Milan (Italy)
  • 2 IRCCS MultiMedica, Milan, Italy , Milan (Italy)
  • 3 Universidade Católica de Brasília, Taguatinga, DF, 71966-700, Brazil , Taguatinga (Brazil)
  • 4 Università degli Studi di Milano, Milan, 20142, Italy , Milan (Italy)
  • 5 Ospedale San Paolo, ASST Santi Paolo e Carlo, Milan, Italy , Milan (Italy)
Type
Published Article
Journal
Cardiovascular Diabetology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jun 09, 2021
Volume
20
Issue
1
Identifiers
DOI: 10.1186/s12933-021-01310-w
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundInformation about the renin–angiotensin–aldosterone system (RAAS) in obese individuals before and after bariatric surgery is scarce. Aim of this study was to analyze the RAAS in severely obese subjects, in relation to anthropometric and metabolic variables, with special reference to glucose tolerance.Methods239 subjects were evaluated at baseline, and 181 one year after bariatric surgery [laparoscopic gastric banding (LAGB)].ResultsAt baseline, renin (plasma renin activity, PRA) was increased from normal to glucose tolerance and more in diabetes, also correlating with ferritin. After LAGB, the decrease of PRA and aldosterone was significant in hypertensive, but not in normotensive subjects, and correlatied with decrease of ferritin. PRA and glucose levels were predictive of persistent hypertension 1 year after LAGB.ConclusionsThese data support the role of RAAS in the pathophysiology of glucose homeostasis, and in the regulation of blood pressure in obesity. Ferritin, as a proxy of subclinical inflammation, could be another factor contributing to the cross-talk between RAAS and glucose metabolism.

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