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A high occurrence of BRCA1 and BRCA2 mutations among Czech hereditary breast and breast-ovarian cancer families.

Authors
  • Machácková, E1
  • Foretová, L
  • Navrátilová, M
  • Valík, D
  • Claes, K
  • Messiaen, L
Type
Published Article
Journal
Casopis lekaru ceskych
Publication Date
Oct 11, 2000
Volume
139
Issue
20
Pages
635–637
Identifiers
PMID: 11192759
Source
Medline
License
Unknown

Abstract

Molecular genetic testing of BRCA1 and BRCA2 genes in high-risk women with breast/ovarian cancer is effective in determining genetic predisposition to cancer. Spectrum of mutations found in both genes is variable and further investigation is needed for estimation of more frequent or "founder" mutations. The genetic counselling and preventive clinical follow-up of gene carriers has to be part of the genetic program.

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