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High levels of serum soluble TWEAK are associated with neuroinflammation during multiple sclerosis

Authors
  • Maarouf, Adil1, 2, 3
  • Stephan, Delphine4
  • Ranjeva, Marie-Pierre1, 2, 3
  • Ranjeva, Jean-Philippe1
  • Pelletier, Jean1, 3
  • Audoin, Bertrand1, 3
  • Khrestchatisky, Michel4
  • Desplat-Jégo, Sophie4, 5
  • 1 Aix-Marseille Univ, CNRS, CRMBM, Marseille, France , Marseille (France)
  • 2 Assistance Publique-Hôpitaux de Marseille, Hôpital de la Timone, CEMEREM, Marseille, France , Marseille (France)
  • 3 Assistance Publique-Hôpitaux de Marseille, Hôpital de la Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, Marseille, France , Marseille (France)
  • 4 Aix-Marseille Université, CNRS, Faculté de Médecine, Institut de NeuroPhysiopathologie (INP), Inst Neurophysiopathol, 51 Bd P. Drammard, Marseille, 13015, France , Marseille (France)
  • 5 Assistance Publique-Hôpitaux de Marseille, Hôpital de la Conception, Pôle de Biologie, Service d’Immunologie, Marseille, 13005, France , Marseille (France)
Type
Published Article
Journal
Journal of Translational Medicine
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Feb 20, 2019
Volume
17
Issue
1
Identifiers
DOI: 10.1186/s12967-019-1789-3
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundInflammation and demyelination are the main processes in multiple sclerosis. Nevertheless, to date, blood biomarkers of inflammation are lacking. TWEAK, a transmembrane protein that belongs to the TNF ligand family, has been previously identified as a potential candidate.MethodsTwenty-eight patients (9 males, 19 females) were prospectively included after a first clinical episode suggestive of multiple sclerosis and clinically followed during 3 years. Fifty-seven healthy controls were also included. TWEAK serum levels and MRI exams including magnetization transfer imaging were performed at baseline, 6- and 12-month follow-up.ResultsTWEAK serum levels were significantly increased in the patient group (mean baseline = 1086 ± 493 pg/mL, mean M6 = 624 ± 302 pg/mL and mean M12 = 578 ± 245 pg/mL) compared to healthy controls (mean = 467 ± 177 pg/mL; respectively p < 0.0001, 0.01 and 0.06). Serum levels of soluble TWEAK were significantly increased during relapses, compared to time periods without any relapse (respectively 935 ± 489 pg/mL and 611 ± 292 pg/mL, p = 0.0005). Moreover, patients presenting at least one gadolinium-enhanced CNS lesion at baseline (n = 7) displayed significantly increased serum TWEAK levels in comparison with patients without any gadolinium-enhanced lesion at baseline (n = 21) (respectively 1421 ± 657 pg/mL vs 975 ± 382 pg/mL; p = 0.02). Finally, no correlation was evidenced between TWEAK serum levels and the extent of brain tissue damage assessed by magnetization transfer ratio.ConclusionsThe present study showed that TWEAK serum levels are increased in MS patients, in relation to the disease activity. This simple and reproducible serum test could be used as a marker of ongoing inflammation, contributing in the follow-up and the care of MS patients. Thus, TWEAK is a promising serum marker of the best window to perform brain MRI, optimizing the disease control in patients.

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