Affordable Access

deepdyve-link
Publisher Website

High K+-induced contraction requires depolarization-induced Ca2+ release from internal stores in rat gut smooth muscle.

Authors
  • Kirschstein, Timo
  • Rehberg, Mirko
  • Bajorat, Rika
  • Tokay, Tursonjan
  • Porath, Katrin
  • Köhling, Rüdiger
Type
Published Article
Journal
Acta Pharmacologica Sinica
Publisher
Springer Nature
Publication Date
Aug 01, 2009
Volume
30
Issue
8
Pages
1123–1131
Identifiers
DOI: 10.1038/aps.2009.98
PMID: 19578389
Source
Medline
License
Unknown

Abstract

We conclude that there are parallel mechanisms of depolarization-induced smooth muscle contraction via (a) Ca2+ entry and (b) Ca2+ entry-independent, depolarization-induced Ca2+-release through ryanodine receptors and IP3, with the latter being dependent on phospholipase C activation.

Report this publication

Statistics

Seen <100 times