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High interstitial fluid pressure - an obstacle in cancer therapy.

Authors
  • Heldin, Carl-Henrik
  • Rubin, Kristofer
  • Pietras, Kristian
  • Ostman, Arne
Type
Published Article
Journal
Nat Rev Cancer
Publication Date
Oct 01, 2004
Volume
4
Issue
10
Pages
806–813
Identifiers
PMID: 15510161
Source
Medline
License
Unknown

Abstract

Many solid tumours show an increased interstitial fluid pressure (IFP), which forms a barrier to transcapillary transport. This barrier is an obstacle in tumour treatment, as it results in inefficient uptake of therapeutic agents. There are a number of factors that contribute to increased IFP in the tumour, such as vessel abnormalities, fibrosis and contraction of the interstitial matrix. Lowering the tumour IFP with specific signal-transduction antagonists might be a useful approach to improving anticancer drug efficacy.

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