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High incidence of antibodies to hepatitis C virus in alcoholic cirrhosis: fact or fiction?

Authors
  • Bode, J C
  • Biermann, J
  • Kohse, K P
  • Walker, S
  • Bode, C
Type
Published Article
Journal
Alcohol and alcoholism (Oxford, Oxfordshire)
Publication Date
Jan 01, 1991
Volume
26
Issue
2
Pages
111–114
Identifiers
PMID: 1652249
Source
Medline
License
Unknown

Abstract

An enzyme immunoassay (Ortho-HCV ELISA) for antibodies against the hepatitis C virus was used to test serum samples from 39 patients with alcoholic cirrhosis and 34 patients with alcoholic hepatitis or fatty liver. The frequency of a positive result in the cirrhotics was significantly higher than in the alcoholics without cirrhosis (38.5% vs 8.8%, P less than 0.01). However, the positive results in the cirrhotics were associated with high gammaglobulin concentrations, and optical density values in the assay correlated closely with serum globulin (r = 0.73, P less than 0.01). The findings suggest that serum from patients with alcoholic cirrhosis may contain a component that give false-positive results in the assay.

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