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High ICP as trigger of proinflammatory IL-6 cytokine activation in aneurysmal subarachnoid hemorrhage.

Authors
  • Graetz, Daniela
  • Nagel, Alexandra
  • Schlenk, Florian
  • Sakowitz, Oliver
  • Vajkoczy, Peter
  • Sarrafzadeh, Asita
Type
Published Article
Journal
Neurological Research
Publisher
Maney Publishing
Publication Date
Sep 01, 2010
Volume
32
Issue
7
Pages
728–735
Identifiers
DOI: 10.1179/016164109X12464612122650
PMID: 19682408
Source
Medline
License
Unknown

Abstract

Intracranial hypertension is associated with a strong activation of the inflammatory cascade in the brain and systemic circulation, and might be underestimated as proinflammmatory trigger in the pathogenesis of complications after SAH. Future therapies targeting anti-inflammatory response in plasma may help to reduce the inflammatory cascade responsible for development of intracranial hypertension.

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