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High HOMA-IR, adjusted for puberty, relates to the metabolic syndrome in overweight and obese Chilean youths.

Authors
  • Burrows, Raquel A1
  • Leiva, Laura B
  • Weisstaub, Gerardo
  • Lera, Lydia M
  • Albala, Cecilia B
  • Blanco, Estela
  • Gahagan, Sheila
  • 1 Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile. , (Chile)
Type
Published Article
Journal
Pediatric Diabetes
Publisher
Wiley (Blackwell Publishing)
Publication Date
May 01, 2011
Volume
12
Issue
3 Pt 2
Pages
212–218
Identifiers
DOI: 10.1111/j.1399-5448.2010.00685.x
PMID: 21426454
Source
Medline
License
Unknown

Abstract

In a large clinical sample of overweight and obese Chilean youths, HOMA-IR ≥ 75th percentile was significantly associated with the cluster of factors referred to as the MetS. We emphasize the importance of establishing percentiles for HOMA-IR based on a normative sample and taking Tanner stage into account. Although BMI is easy to assess and interpret with minimal costs in a clinical setting, adding HOMA-IR explains more of the variance in the MetS than BMI Z-score alone.

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