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A high frequency of inherited deficiency of complement component C4 in Darwin Aborigines.

Authors
  • Ranford, P
  • Hay, J
  • Serjeantson, S W
  • Dunckley, H
Type
Published Article
Journal
Australian and New Zealand journal of medicine
Publication Date
Aug 01, 1987
Volume
17
Issue
4
Pages
420–423
Identifiers
PMID: 3501712
Source
Medline
License
Unknown

Abstract

A high frequency of serum complement component C4A deficiency may explain the higher prevalence and greater severity of systemic lupus erythematosus reported in Australian Aborigines. Inherited deficiencies of serum complement components C4A, C4B, and C2 were examined in two Australian Aboriginal populations from Darwin and Alice Springs and compared with the prevalence of complement deficiencies in white Australian blood donors. The frequency of C4A deficiency alleles was 29% in Darwin Aborigines compared with 12% in Alice Springs and 17% in Canberra blood donors. Partial C4B deficiency was also higher in Darwin Aborigines than in the other populations. Inherited deficiency of serum complement component C2 was not observed.

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