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High frequency of cord blood lymphocytes against mycobacterial 65-kDa heat-shock protein.

Authors
Type
Published Article
Journal
European journal of immunology
Publication Date
Volume
22
Issue
6
Pages
1667–1669
Identifiers
PMID: 1601047
Source
Medline
License
Unknown

Abstract

A high frequency of nonadherent mononuclear cells in human cord blood proliferates in response to mycobacterial 65-kDa heat-shock protein. The frequency range in cord blood is not different from that in peripheral blood of Bacillus Calmette-Guérin vaccinated adults. In comparison we found 10 to 100 times lower frequencies to purified protein derivative in nonadherent cord blood mononuclear cells than in adult peripheral blood mononuclear cells. These findings may provide experimental support for Cohen's theory of the immunological homonculus.

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