A high frequency of nonadherent mononuclear cells in human cord blood proliferates in response to mycobacterial 65-kDa heat-shock protein. The frequency range in cord blood is not different from that in peripheral blood of Bacillus Calmette-Guérin vaccinated adults. In comparison we found 10 to 100 times lower frequencies to purified protein derivative in nonadherent cord blood mononuclear cells than in adult peripheral blood mononuclear cells. These findings may provide experimental support for Cohen's theory of the immunological homonculus.
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This record was last updated on 07/02/2016 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/1601047