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High-frequency attenuation of the cone ERG and ON-response deficits in X-linked retinoschisis.

Authors
  • Alexander, K R
  • Barnes, C S
  • Fishman, G A
Type
Published Article
Journal
Investigative Ophthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
Aug 01, 2001
Volume
42
Issue
9
Pages
2094–2101
Identifiers
PMID: 11481277
Source
Medline
License
Unknown

Abstract

The overall pattern of findings indicates that two factors contribute to the preferential ON-response deficit in XLRS: first, a high-frequency attenuation of the cone photoreceptor response that effectively produces a low-pass stimulus for the postreceptoral pathway and that affects the ON response more than the OFF response and, second, a relatively greater attenuation of the ON- than of the OFF-bipolar cell response that is evident in the aberrant response to the sawtooth fundamental.

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