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High-dose chemotherapy with autologous hematopoietic stem cell transplantation in patients with multiple myeloma.

Authors
  • Gertz, Morie A
  • Lacy, Martha Q
  • Dispenzieri, Angela
  • Hayman, Suzanne R
  • Kumar, Shaji K
Type
Published Article
Journal
Expert Review of Anticancer Therapy
Publisher
Informa UK (Taylor & Francis)
Publication Date
Mar 01, 2006
Volume
6
Issue
3
Pages
343–360
Identifiers
PMID: 16503852
Source
Medline
License
Unknown

Abstract

Multiple myeloma, for all practical purposes, remains an incurable malignancy; however, 5-year survival has improved substantially during the past 30 years. A major contribution to improved outcome is the use of high-dose chemotherapy and stem cell transplantation. This multifaceted approach to therapy requires an understanding of appropriate induction therapy, techniques for stem cell mobilization, appropriate conditioning and supportive care. Also of importance are prognosis, features that predict outcome, the suitability of transplant candidates, and post-transplantation maintenance therapy.

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