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High Density-Lipoprotein Subfractions of Patients Using Cardio-Selective Beta-Blockers

Authors
  • Kuster, Gabriela M.1
  • Amann, Franz Wolfgang1
  • Neuenschwander, Christian1
  • Drexel, Heinz1
  • 1 University Hospital, Division of Cardiology, Department of Medicine, Raemistrasse 100, Zurich, CH-8001, Switzerland , Zurich
Type
Published Article
Journal
Cardiovascular Drugs and Therapy
Publisher
Kluwer Academic Publishers
Publication Date
Mar 01, 2002
Volume
16
Issue
2
Pages
127–131
Identifiers
DOI: 10.1023/A:1015753432426
Source
Springer Nature
Keywords
License
Yellow

Abstract

Treatment of hypertension with beta-adrenergic blockers (BB) slightly increases plasma triglycerides and decreases high density lipoprotein (HDL) cholesterol levels. However, only little is known about BB-related lipid changes in patients with coronary artery disease (CAD), who usually a priori have decreased HDL cholesterol levels; and even less data exist on HDL subfraction cholesterol in these patients. We therefore quantified levels of lipids, lipoprotein lipids including HDL2 and HDL3 cholesterol, and apolipoproteins in 107 consecutive men undergoing elective coronary angiography. Of the 107 patients, 84 had angiographically established coronary atherosclerosis (≥1 lesion with ≥50% narrowing, CAD+), and 23 had no major lesion (CAD−); 67 were taking ß1-selective BB (metoprolol or atenolol) for treatment of angina and/or hypertension and 40 were not. Patients using BB had significantly higher cholesterol levels than patients not using BB (5.99 ± 0.93 vs. 5.63 ± 1.07 mmol/l, mean ± SD, p = 0.029). Their HDL cholesterol and HDL2 cholesterol levels were significantly lower (1.19 ± 0.27 vs. 1.28 ± 0.33 mmol/l, p = 0.048, and 0.22 ± 0.12 vs. 0.27 ± 0.18 mmol/l, p = 0.038, respectively). Accordingly, the total cholesterol/HDL cholesterol ratio was significantly higher in patients taking BB than in those not taking BB (5.23 ± 1.27 vs. 4.68 ± 1.63, p = 0.010). Considering CAD+ and CAD− patients separately, there was a trend towards lower HDL cholesterol and its subfractions with significantly lower HDL2 cholesterol in patients with BB in the CAD− group, suggesting a stronger dyslipidemic effect of BB in these patients with a priori normal or near normal baseline lipid levels.

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