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High affinity phenylglycinol-based NK1 receptor antagonists.

Authors
  • Owens, A P
  • Harrison, T
  • Moseley, J D
  • Swain, C J
  • Sadowski, S
  • Cascieri, M A
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Jan 06, 1998
Volume
8
Issue
1
Pages
51–56
Identifiers
PMID: 9871627
Source
Medline
License
Unknown

Abstract

Heterocyclic replacements for the carboxamido group of the previously disclosed phenylglycinol-based human NK1 (hNK1) receptor antagonists have been investigated, ultimately leading to acyclic compounds with sub-nanomolar affinity for the hNK1 receptor.

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