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HIF-1α in epidermis: oxygen sensing, cutaneous angiogenesis, cancer, and non-cancer disorders.

Authors
  • Rezvani, Hamid R
  • Ali, Nsrein
  • Nissen, Lars J
  • Harfouche, Ghida
  • de Verneuil, Hubert
  • Taïeb, Alain
  • Mazurier, Frédéric
Type
Published Article
Journal
Journal of Investigative Dermatology
Publisher
Elsevier
Publication Date
Sep 01, 2011
Volume
131
Issue
9
Pages
1793–1805
Identifiers
DOI: 10.1038/jid.2011.141
PMID: 21633368
Source
Medline
License
Unknown

Abstract

Besides lung, postnatal human epidermis is the only epithelium in direct contact with atmospheric oxygen. Skin epidermal oxygenation occurs mostly through atmospheric oxygen rather than tissue vasculature, resulting in a mildly hypoxic microenvironment that favors increased expression of hypoxia-inducible factor-1α (HIF-1α). Considering the wide spectrum of biological processes, such as angiogenesis, inflammation, bioenergetics, proliferation, motility, and apoptosis, that are regulated by this transcription factor, its high expression level in the epidermis might be important to HIF-1α in skin physiology and pathophysiology. Here, we review the role of HIF-1α in cutaneous angiogenesis, skin tumorigenesis, and several skin disorders.

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