Affordable Access

Hierarchical Self-Assembly of Poly-Pseudorotaxanes into Artificial Microtubules

  • hwang, w.
  • yoo, j.
  • i.-c., hwang
  • lee, j.
  • y.h., ko
  • h.w., kim
  • kim, y.
  • lee, y.
  • m.y., hur
  • k.m., park
  • seo, j.
  • baek, k.
  • kim, k.
Publication Date
Jan 01, 2020
[email protected]
External links


Hierarchical self-assembly of building blocks over multiple length scales is ubiquitous in living organisms. Microtubules are one of the principal cellular components formed by hierarchical self-assembly of nanometer-sized tubulin heterodimers into protofilaments, which then associate to form micron-length-scale, multi-stranded tubes. This peculiar biological process is now mimicked with a fully synthetic molecule, which forms a 1:1 host-guest complex with cucurbit[7]uril as a globular building block, and then polymerizes into linear poly-pseudorotaxanes that associate laterally with each other in a self-shape-complementary manner to form a tubular structure with a length over tens of micrometers. Molecular dynamic simulations suggest that the tubular assembly consists of eight poly-pseudorotaxanes that wind together to form a 4.5 nm wide multi-stranded tubule. / 1 / N

Report this publication


Seen <100 times