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Hhex drives B cells down memory lane

Authors
  • Good-Jacobson, Kim L.1, 1
  • Groom, Joanna R.2, 3
  • 1 Monash University, Clayton, Victoria, Australia , Clayton (Australia)
  • 2 Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia , Parkville (Australia)
  • 3 University of Melbourne, Parkville, Victoria, Australia , Parkville (Australia)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Aug 07, 2020
Volume
21
Issue
9
Pages
968–969
Identifiers
DOI: 10.1038/s41590-020-0763-9
Source
Springer Nature
License
Yellow

Abstract

The combination of single-cell RNA-seq and in vivo CRISPR–Cas9 screens reveal a new circuit that directs germinal center B cells toward a memory B cell phenotype during viral infection.

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