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Heterozygosity of mitogen-activated protein kinase organizer 1 ameliorates diabetic nephropathy and suppresses epithelial-to-mesenchymal transition-like changes in db/db mice.

Authors
  • Loeffler, Ivonne1
  • Liebisch, Marita1
  • Daniel, Christoph2
  • Amann, Kerstin2
  • Wolf, Gunter1
  • 1 Department of Internal Medicine III, University Hospital Jena, Jena, Germany. , (Germany)
  • 2 Department of Nephropathology, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany. , (Germany)
Type
Published Article
Journal
Nephrology Dialysis Transplantation
Publisher
Oxford University Press
Publication Date
Dec 01, 2017
Volume
32
Issue
12
Pages
2017–2034
Identifiers
DOI: 10.1093/ndt/gfx202
PMID: 28992060
Source
Medline
Keywords
License
Unknown

Abstract

These findings reveal that a deletion of one MORG1 allele inhibits the development of DN in db/db mice. The data suggest that the diminished interstitial fibrosis in these mice is a likely consequence of suppressed EMT-like changes.

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