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Heterogeneous Effects of Calorie Content and Nutritional Components Underlie Dietary Influence on Pancreatic Cancer Susceptibility

Authors
  • Dooley, James1, 2, 3
  • Lagou, Vasiliki2, 3
  • Goveia, Jermaine4, 5
  • Ulrich, Anna6
  • Rohlenova, Katerina4, 5
  • Heirman, Nathalie2, 3
  • Karakach, Tobias7, 8
  • Lampi, Yulia2, 3
  • Khan, Shawez4, 5
  • Wang, Jun9, 10
  • Dresselaers, Tom11
  • Himmelreich, Uwe11
  • Gunter, Marc J.12
  • Prokopenko, Inga6, 13, 14
  • Carmeliet, Peter4, 5
  • Liston, Adrian1, 2, 3
  • 1 Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK
  • 2 VIB Center for Brain and Disease Research, VIB, Leuven 3000, Belgium
  • 3 Department of Microbiology and Immunology, KU Leuven-University of Leuven, Leuven 3000, Belgium
  • 4 Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, Leuven 3000, Belgium
  • 5 Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven-University of Leuven, Leuven 3000, Belgium
  • 6 Department of Clinical & Experimental Medicine, University of Surrey, Guildford GU2 7XH, UK
  • 7 Bioinformatics Core Laboratory, Children’s Hospital Research Institute of Manitoba, Winnipeg, MB R3E 3P4, Canada
  • 8 Rady Faculty of Health Sciences, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
  • 9 CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Science, Beijing 100101, China
  • 10 University of Chinese Academy of Sciences, Beijing 100049, China
  • 11 Department of Imaging and Pathology, KU Leuven-University of Leuven, Leuven 3000, Belgium
  • 12 Section of Nutrition and Metabolism, International Agency for Research on Cancer, World Health Organization, 69372 Lyon Cedex 08, France
  • 13 UMR 8199 - EGID, Institut Pasteur de Lille, CNRS, University of Lille, 59000 Lille, France
  • 14 Section of Genetics and Genomics, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London SW7 2AZ, UK
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Jul 14, 2020
Volume
32
Issue
2
Identifiers
DOI: 10.1016/j.celrep.2020.107880
PMID: 32668252
PMCID: PMC7370178
Source
PubMed Central
Keywords
License
Unknown

Abstract

Dooley et al. used parallel analysis of a murine pancreatic cancer model and a human prospective cohort to study the interaction of diet and pancreatic cancer. Both systems identify complex effects with different dietary components, converging on a link between dietary sugar and the cell-cycle checkpoint gene MAD2L1 .

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