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Heterogeneous Effects of Calorie Content and Nutritional Components Underlie Dietary Influence on Pancreatic Cancer Susceptibility

  • Dooley, James1, 2, 3
  • Lagou, Vasiliki2, 3
  • Goveia, Jermaine4, 5
  • Ulrich, Anna6
  • Rohlenova, Katerina4, 5
  • Heirman, Nathalie2, 3
  • Karakach, Tobias7, 8
  • Lampi, Yulia2, 3
  • Khan, Shawez4, 5
  • Wang, Jun9, 10
  • Dresselaers, Tom11
  • Himmelreich, Uwe11
  • Gunter, Marc J.12
  • Prokopenko, Inga6, 13, 14
  • Carmeliet, Peter4, 5
  • Liston, Adrian1, 2, 3
  • 1 Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK
  • 2 VIB Center for Brain and Disease Research, VIB, Leuven 3000, Belgium
  • 3 Department of Microbiology and Immunology, KU Leuven-University of Leuven, Leuven 3000, Belgium
  • 4 Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, Leuven 3000, Belgium
  • 5 Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven-University of Leuven, Leuven 3000, Belgium
  • 6 Department of Clinical & Experimental Medicine, University of Surrey, Guildford GU2 7XH, UK
  • 7 Bioinformatics Core Laboratory, Children’s Hospital Research Institute of Manitoba, Winnipeg, MB R3E 3P4, Canada
  • 8 Rady Faculty of Health Sciences, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
  • 9 CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Science, Beijing 100101, China
  • 10 University of Chinese Academy of Sciences, Beijing 100049, China
  • 11 Department of Imaging and Pathology, KU Leuven-University of Leuven, Leuven 3000, Belgium
  • 12 Section of Nutrition and Metabolism, International Agency for Research on Cancer, World Health Organization, 69372 Lyon Cedex 08, France
  • 13 UMR 8199 - EGID, Institut Pasteur de Lille, CNRS, University of Lille, 59000 Lille, France
  • 14 Section of Genetics and Genomics, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London SW7 2AZ, UK
Published Article
Cell Reports
Publication Date
Jul 14, 2020
DOI: 10.1016/j.celrep.2020.107880
PMID: 32668252
PMCID: PMC7370178
PubMed Central


Dooley et al. used parallel analysis of a murine pancreatic cancer model and a human prospective cohort to study the interaction of diet and pancreatic cancer. Both systems identify complex effects with different dietary components, converging on a link between dietary sugar and the cell-cycle checkpoint gene MAD2L1 .

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