Affordable Access

Heterogeneity of 6'-N-acetyltransferases of type 4 conferring resistance to amikacin and related aminoglycosides in members of the family Enterobacteriaceae.

Authors
  • G Tran Van Nhieu
  • E Collatz
Publication Date
Aug 01, 1988
Source
PMC
Keywords
Disciplines
  • Medicine
License
Unknown

Abstract

DNA-DNA hybridization and immunoblotting were used to assess the relatedness between the 6'-N-acetyltransferases of type 4 encoded by plasmid pAZ007 from a clinical isolate of Serratia marcescens and those encoded by NR79 and R5. The absence of detectable DNA-DNA homology and of immunological cross-reactivity suggests the existence of at least two distinct 6'-N-acetyltransferase type 4 genes that mediate amikacin resistance in gram-negative bacilli.

Report this publication

Statistics

Seen <100 times