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Heterogeneity of Antiviral Responses in the Upper Respiratory Tract Mediates Differential Non-lytic Clearance of Influenza Viruses

Authors
  • Dumm, Rebekah E.1
  • Wellford, Sebastian A.2
  • Moseman, E. Ashley2
  • Heaton, Nicholas S.1, 3
  • 1 Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA
  • 2 Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA
  • 3 Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Sep 01, 2020
Volume
32
Issue
9
Pages
108103–108103
Identifiers
DOI: 10.1016/j.celrep.2020.108103
PMID: 32877682
PMCID: PMC7462569
Source
PubMed Central
Keywords
License
Unknown

Abstract

In the upper respiratory tract, different cell types respond in different ways early after viral infection. Dumm et al. show that influenza B virus targets olfactory sensory neurons, but these neurons induce interferon-stimulated genes to rapidly clear the virus non-lytically and protect the CNS from disseminated infection.

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