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[Heteroassociation of antibiotic norfloxacin with aromatic vitamins in aqueous solution].

Authors
  • Evstigneev, M P
  • Rybakova, K A
  • Davies, D B
Type
Published Article
Journal
Biofizika
Publication Date
Jan 01, 2006
Volume
51
Issue
4
Pages
661–668
Identifiers
PMID: 16909844
Source
Medline
License
Unknown

Abstract

The heteroassociation of the antibacterial antibiotic norfloxacin with aromatic vitamins nicotineamide and flavin mononucleotide in aqueous solution has been studied by 1H NMR spectroscopy (503 MHz). Equilibrium constants, induced proton chemical shifts, and the thermodynamic parameters (deltaH, deltaS) of the heteroassociation of molecules were determined from the concentration and temperature dependences of chemical shifts of protons of interacting aromatic molecules. An analysis of the results indicates the formation of heterocomplexes between the molecules of the vitamins and norfloxacin, which is caused by stacking interactions between aromatic chromophores and an additional intermolecular hydrogen bond in the norfloxacin-nicotinamide system. Based on the analysis of induced chemical shifts of protons of molecules, the most probable spatial structures 1:1 of norfloxacin-flavin mononucleitide and norfloxacin-nicotinamide heterocomolexes were determined by the methods of molecular modeling using the X-PLOR program.

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