Affordable Access

deepdyve-link
Publisher Website

Heteroaryl chalcones: design, synthesis, X-ray crystal structures and biological evaluation.

Authors
  • Kumar, C S Chidan1
  • Loh, Wan-Sin
  • Ooi, Chin Wei
  • Quah, Ching Kheng
  • Fun, Hoong-Kun
  • 1 Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang 11800 USM, Malaysia. [email protected] , (Malaysia)
Type
Published Article
Journal
Molecules
Publisher
MDPI AG
Publication Date
Oct 15, 2013
Volume
18
Issue
10
Pages
12707–12724
Identifiers
DOI: 10.3390/molecules181012707
PMID: 24132195
Source
Medline
Language
English
License
Unknown

Abstract

Chalcone derivatives have attracted increasing attention due to their numerous pharmacological activities. Changes in their structures have displayed high degree of diversity that has proven to result in a broad spectrum of biological activities. The present study highlights the synthesis of some halogen substituted chalcones 3(a-i) containing the 5-chlorothiophene moiety, their X-ray crystal structures and the evaluation of possible biological activities such as antibacterial, antifungal and reducing power abilities. The results indicate the tested compounds show a varied range of inhibition values against all the tested microbial strains. Compound 3c with a p-fluoro substituent on the phenyl ring exhibits elevated antimicrobial activity, whereas the compounds 3e and 3f displayed the least antimicrobial activities. The compounds 3d, 3e, 3f and 3i showed good ferric and cupric reducing abilities, and the compounds 3b and 3c showed the weakest reducing power in the series.

Report this publication

Statistics

Seen <100 times