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HERV-K and HERV-W transcriptional activity in myalgic encephalomyelitis/chronic fatigue syndrome

Authors
  • Rodrigues, Lucas S.1
  • da Silva Nali, Luiz H.1, 2
  • Leal, Cibele O. D.1
  • Sabino, Ester C.1, 3
  • Lacerda, Eliana M.4
  • Kingdon, Caroline C.4
  • Nacul, Luis4
  • Romano, Camila M.1, 5
  • 1 Universidade de São Paulo, Laboratório de Virologia, Instituto de Medicina Tropical de São Paulo, Rua Dr. Enéas de Carvalho Aguiar, 470, São Paulo, SP, 05403-000, Brazil , São Paulo (Brazil)
  • 2 Universidade Santo Amaro, Pós-Graduação em Ciências da Saúde, São Paulo, Brazil , São Paulo (Brazil)
  • 3 Faculdade de Medicina da Universidade de São Paulo, Departamento de Moléstias Infecciosas e Parasitárias, São Paulo, Brazil , São Paulo (Brazil)
  • 4 London School of Hygiene and Tropical Medicine, Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London, UK , London (United Kingdom)
  • 5 Universidade de São Paulo, Hospital das Clinicas HCFMUSP (LIM52), Faculdade de Medicina, São Paulo, Brazil , São Paulo (Brazil)
Type
Published Article
Journal
Autoimmunity Highlights
Publisher
BioMed Central
Publication Date
Nov 15, 2019
Volume
10
Issue
1
Identifiers
DOI: 10.1186/s13317-019-0122-8
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundChronic fatigue syndrome/myalgic encephalomyelitis (CFS/MS) is an incapacitating chronic disease that dramatically compromise the life quality. The CFS/ME pathogenesis is multifactorial, and it is believed that immunological, metabolic and environmental factors play a role. It is well documented an increased activity of Human endogenous retroviruses (HERVs) from different families in autoimmune and neurological diseases, making these elements good candidates for biomarkers or even triggers for such diseases.MethodsHere the expression of Endogenous retroviruses K and W (HERV-K and HERV-W) was determined in blood from moderately and severely affected ME/CFS patients through real time PCR.ResultsHERV-K was overexpressed only in moderately affected individuals but HERV-W showed no difference.ConclusionsThis is the first report about HERV-K differential expression in moderate ME/CFS. Although the relationship between HERVs and ME/CFS has yet to be proven, the observation of this phenomenon deserves further attention.

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