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Herpesvirus Epigenetic Reprogramming and Oncogenesis

Authors
  • Pei, Yonggang
  • Wong, Josiah Hiu-yuen
  • Robertson, Erle S.
Type
Published Article
Publisher
Annual Reviews
Publication Date
Sep 29, 2020
Volume
7
Pages
309–331
Identifiers
DOI: 10.1146/annurev-virology-020420-014025
Source
Annual Reviews
Keywords
License
Yellow

Abstract

Among all of the known biological carcinogens, Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) are two of the classical oncogenic herpesviruses known to induce the oncogenic phenotype. Many studies have revealed important functions related to epigenetic alterations of the EBV and KSHV genomes that mediate oncogenesis, but the detailed mechanisms are not fully understood. It is also challenging to fully describe the critical cellular events that drive oncogenesis as well as a comprehensive map of the molecular contributors. This review introduces the roles of epigenetic modifications of these viral genomes, including DNA methylation, histone modification, chromatin remodeling, and noncoding RNA expression, and elucidates potential strategies utilized for inducing oncogenesis by these human gammaherpesviruses.

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