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Herpes simplex virus hepatitis in mice: effects of treatment with trisodium phosphonoformate.

Authors
  • Ulbricht, A
  • Färber, I
  • Wutzler, P
Type
Published Article
Journal
Acta virologica
Publication Date
Dec 01, 1985
Volume
29
Issue
6
Pages
493–498
Identifiers
PMID: 2869661
Source
Medline
License
Unknown

Abstract

Clinical isolates of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) induced focal necrotic hepatitis in ICR/Schö mice. The extent of the hepatitis could be considerably reduced by trisodium phosphonoformate (PFA) administered for 3 days in a daily dose of 400-600 mg/kg. The HSV hepatitis in mice could serve as a suitable model for testing antiherpetic drugs.

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