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Herpes simplex-hepatitus use of immunoperoxidase to demonstrate the viral antigen in hepatocytes.

Authors
  • Marrie, T J
  • McDonald, A T
  • Conen, P E
  • Boudreau, S F
Type
Published Article
Journal
Gastroenterology
Publisher
Elsevier
Publication Date
Jan 01, 1982
Volume
82
Issue
1
Pages
71–76
Identifiers
PMID: 6273252
Source
Medline
License
Unknown

Abstract

In this paper we describe 2 patients with herpes simplex hepatitis. Submassive liver necrosis occurred in both patients, one of whom survived. Notable in the clinical course of both patients was the almost simultaneous occurrence of three events-fever, marked elevation of serum transaminases, and leukopenia. Using an immunoperoxidase staining technique we demonstrated herpes simplex viral antigen in the nucleus, cytoplasm, and cell membrane of affected hepatocytes.

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