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Herbal-Based Formulation Containing Eurycoma longifolia and Labisia pumila Aqueous Extracts: Safe for Consumption?

Authors
  • Teh, Bee Ping1
  • Ahmad, Norzahirah1
  • Ibnu Rasid, Elda Nurafnie1
  • Zolkifli, Nor Azlina1
  • [email protected], Umi Rubiah1
  • Mohamed Yusoff, Norliyana1
  • Zulkapli, Azlina
  • Japri, Norfarahana1
  • Lee, June Chelyn1
  • Muhammad, Hussin1
  • 1 (H.M.)
Type
Published Article
Journal
Pharmaceuticals
Publisher
MDPI AG
Publication Date
Feb 10, 2021
Volume
14
Issue
2
Identifiers
DOI: 10.3390/ph14020142
PMID: 33579048
PMCID: PMC7916751
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Green

Abstract

A combined polyherbal formulation containing tongkat ali ( Eurycoma longifolia ) and kacip fatimah ( Labisia pumila ) aqueous extracts was evaluated for its safety aspect. A repeated dose 28-day toxicity study using Wistar rats was conducted where the polyherbal formulation was administered at doses 125, 500 and 2000 mg/kg body weight to male and female treatment groups daily via oral gavage, with rats receiving only water as the control group. In-life parameters measured include monitoring of food and water consumption and clinical and functional observations. On day 29, blood was collected for haematological and biochemical analysis. The rats were necropsied and the organs were collected for histopathological examination. This study showed that the combined formulation did not induce any significant toxicity effect at any dose level in terms of morbidity, mortality, behaviour, functional observation, body weight, food and water consumption, whole blood haematology and serum biochemistry. However, there were some microscopic changes in the histopathological examinations of some organs given 2000 mg/kg body weight, which may suggest an early response to the polyherbal formulation. From this study, the no observed adverse effect level is estimated to be more than 500 mg/kg body weight but not exceeding 2000 mg/kg body weight. The observed effects at the highest dose indicate the need for further study of longer dosing duration.

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