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HER-2/neu amplification testing in breast cancer by multiplex ligation-dependent probe amplification in comparison with immunohistochemistry and in situ hybridization.

Authors
  • Moelans, Cathy B
  • de Weger, Roel A
  • van Blokland, Marja T M
  • Ezendam, Chantal
  • Elshof, Sabrina
  • Tilanus, Marcel G J
  • van Diest, Paul J
Type
Published Article
Journal
Cellular oncology : the official journal of the International Society for Cellular Oncology
Publication Date
Jan 01, 2009
Volume
31
Issue
1
Pages
1–10
Identifiers
PMID: 19096145
Source
Medline
License
Unknown

Abstract

MLPA is a fast, accurate and cheap method to detect breast cancer HER-2/neu amplification in small quantities of DNA extracted from paraffin blocks, and thereby a reliable alternative to FISH and CISH.

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