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Hepatoprotective effects of chamazulene against alcohol-induced liver damage by alleviation of oxidative stress in rat models

Authors
  • Wang, Xu1
  • Dong, Ke1
  • Ma, Yujing1
  • Jin, Qizhi1
  • Yin, Shujun1
  • Wang, Shan2
  • 1 No. 2 Ward of Hepatobiliary Surgery, Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital, Sichuan, 610047 , (China)
  • 2 Department of Echocardiography & Noninvasive Cardiology Laboratory, Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital, Sichuan, 610047 , (China)
Type
Published Article
Journal
Open Life Sciences
Publisher
Walter de Gruyter GmbH
Publication Date
Apr 20, 2020
Volume
15
Issue
1
Pages
251–258
Identifiers
DOI: 10.1515/biol-2020-0026
Source
De Gruyter
Keywords
License
Green

Abstract

Liver injury and disease caused by alcohol is a common complication to human health worldwide. Chamazulene is a natural proazulene with antioxidant and anti-inflammatory properties. This study aims to investigate the hepatoprotective effects of chamazulene against ethanol-induced liver injury in rat models. Adult Wistar rats were orally treated with 50% v/v ethanol (8–12 mL/kg body weight [b.w.]) for 6 weeks to induce alcoholic liver injury. Chamazulene was administered orally to rats 1 h prior to ethanol administration at the doses of 25 and 50 mg/kg b.w. for 6 weeks. Silymarin, a commercial drug for hepatoprotection, was orally administered (50 mg/kg b.w.) for the positive control group. Chamazulene significantly reduced (p < 0.05) the levels of serum alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, and malondialdehyde, whereas the levels of antioxidant enzymes (glutathione peroxidase, catalase, and superoxide dismutase) and reduced glutathione were significantly restored (p < 0.05) in contrast to the ethanol model group. The levels of pro-inflammatory cytokines (tumour necrosis factor-α and interleukin-6) were suppressed by chamazulene (p < 0.05) with relevance to ethanol-induced liver injury. Histopathological alterations were convincing in the chamazulene-treated groups, which showed protective effects against alcoholic liver injury. Chamazulene has a significant hepatoprotective effect against ethanol-induced liver injury through alleviation of oxidative stress and prevention of inflammation.

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