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Hepatocyte nuclear factor (HNF) 4α expression distinguishes ampullary cancer subtypes and prognosis after resection.

Authors
  • Ehehalt, Florian
  • Rümmele, Petra
  • Kersting, Stephan
  • Lang-Schwarz, Corinna
  • Rückert, Felix
  • Hartmann, Arndt
  • Dietmaier, Wolfgang
  • Terracciano, Luigi
  • Aust, Daniela E
  • Jahnke, Beatrix
  • Saeger, Hans-Detlev
  • Pilarsky, Christian
  • Grützmann, Robert
Type
Published Article
Journal
Annals of Surgery
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Aug 01, 2011
Volume
254
Issue
2
Pages
302–310
Identifiers
DOI: 10.1097/SLA.0b013e31821994a8
PMID: 21494118
Source
Medline
License
Unknown

Abstract

Immunohistochemical determination of HNF4α expression is an effective tool for distinguishing different AC subtypes. Similarly, HNF4α protein expression is an independent predictor of favorable prognosis in carcinoma of the papilla of Vater and may serve for risk stratification after curative resection.

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