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Hepatitis C virus non-structural 5A protein can enhance full-length core protein-induced nuclear factor-kappaB activation.

Authors
  • Liao, Qing-Jiao
  • Ye, Lin-Bai
  • Timani, Khalid Amine
  • She, Ying-Long
  • Yang, Xiao-Jun
  • Ye, Li
  • Wu, Zheng-Hui
Type
Published Article
Journal
World Journal of Gastroenterology
Publisher
Baishideng Publishing Group Co
Publication Date
Nov 07, 2005
Volume
11
Issue
41
Pages
6433–6439
Identifiers
PMID: 16425412
Source
Medline
License
Unknown

Abstract

NF-kappaB is the key transcription factor that can activate many genes that are involved in the cellular immune response and inflammation. Coexpression of the full-length core protein along with NS5A can enhance the NF-kappaB activation, and this activation may play a significant role in chronic liver diseases including hepatocellular carcinoma associated with HCV infection.

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