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Hepatitis C virus entry.

Authors
  • Zeisel, Mirjam B1
  • Felmlee, Daniel J
  • Baumert, Thomas F
Type
Published Article
Journal
Current topics in microbiology and immunology
Publication Date
Jan 01, 2013
Volume
369
Pages
87–112
Identifiers
DOI: 10.1007/978-3-642-27340-7_4
PMID: 23463198
Source
Medline
License
Unknown

Abstract

Hepatitis C virus (HCV) is a hepatotropic virus and a major cause of chronic hepatitis and liver disease worldwide. Initial interactions between HCV virions and hepatocytes are required for productive viral infection and initiation of the viral life cycle. Furthermore, HCV entry contributes to the tissue tropism and species specificity of this virus. The elucidation of these interactions is critical, not only to understand the pathogenesis of HCV infection, but also to design efficient antiviral strategies and vaccines. This review summarizes our current knowledge of the host factors required for the HCV-host interactions during HCV binding and entry, our understanding of the molecular mechanisms underlying HCV entry into target cells, and the relevance of HCV entry for the pathogenesis of liver disease, antiviral therapy, and vaccine development.

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