Affordable Access

deepdyve-link
Publisher Website

Hepatitis B virus-induced hepatocellular carcinoma

Authors
  • Xu, Cheng
  • Zhou, Wence
  • Wang, Yuming
  • Qiao, Liang1, 2, 3, 4, 5, 6, 7, 8, 9
  • 1 Institute for Infectious Diseases
  • 2 Southwest Hospital
  • 3 Third Military Medical University
  • 4 The Department of General Surgery II
  • 5 The First Hospital of Lanzhou University
  • 6 Storr Liver Unit
  • 7 University of Sydney
  • 8 Westmead Millennium Institute
  • 9 Westmead Hospital
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Jan 01, 2013
Volume
345
Issue
2
Pages
216–222
Identifiers
DOI: 10.1016/j.canlet.2013.08.035
Source
Elsevier
Keywords
License
Unknown

Abstract

Many factors are considered to contribute to hepatitis B virus (HBV) associated hepatocellular carcinoma (HCC), including products of HBV, HBV integration and mutation, and host susceptibility. HBV X protein (HBx) can interfere with several signal pathways that associated with cell proliferation and apoptosis, and the impact of HBx C-terminal truncation in the development of HCC has been implicated. Recent studies by advanced sequencing technologies have revealed recurrent HBV DNA integration sites in hepatoma cells and susceptible genes/SNPs play an important role in the pathogenesis of liver cancer. Epigenetic changes, immune and inflammatory factors are also important contributing factors for liver cancer. This mini-review provides an overview on the recent development of HBV induced HCC.

Report this publication

Statistics

Seen <100 times