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Hepatitis B virus infection in Taiwan: The role of NTCP rs2296651 variant in relation to sex.

Authors
  • Nfor, O N1
  • Wu, M-F2, 3
  • Debnath, T1
  • Lee, C-T2, 4
  • Lee, W1
  • Liu, W-H1
  • Tantoh, D M1
  • Hsu, S-Y1
  • Liaw, Y-P1, 5
  • 1 Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City, Taiwan. , (Taiwan)
  • 2 School of Medicine, Chung Shan Medical University, Taichung City, Taiwan. , (Taiwan)
  • 3 Divisions of Medical Oncology and Pulmonary Medicine, Chung Shan Medical University Hospital, Taichung City, Taiwan. , (Taiwan)
  • 4 Department of Psychiatry, Chung Shan Medical University Hospital, Taichung City, Taiwan. , (Taiwan)
  • 5 Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung City, Taiwan. , (Taiwan)
Type
Published Article
Journal
Journal of Viral Hepatitis
Publisher
Wiley (Blackwell Publishing)
Publication Date
Oct 01, 2018
Volume
25
Issue
10
Pages
1116–1120
Identifiers
DOI: 10.1111/jvh.12912
PMID: 29660219
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Sodium taurocholate cotransporting polypeptide (NTCP) is a functional receptor for hepatitis B virus (HBV) infection. NTCP rs2296651 is believed to be an Asian-specific variant responsible for HBV susceptibility. We investigated the relationship between rs2296651 and HBV infection in Taiwan based on stratification by gender and menopausal status. We recruited 10 017 Taiwan Biobank participants aged 30-70 years with complete genetic data and sociodemographic information. Gender-stratified multivariate logistic regression models were used to determine the relationship between NTCP variant and HBV infection. Among individuals with HBV infection, the genotype frequencies of GG, AG and AA in women were 0.85, 0.15 and 0 while those in men were 0.82, 0.18 and 0, respectively. The multivariate-adjusted odds ratios (OR) of HBV infection were 0.77 (95% CI 0.59-0.10) in women and 0.98 (95% CI 0.79-1.20) in men. The adjusted OR was 0.87 (CI 0.63-1.19) in premenopausal and 0.59 (0.36-0.97) in postmenopausal women. We found that genetic variation in the HBV receptor gene (NTCP) was significantly associated with a decreased risk of HBV infection in Taiwanese women. © 2018 The Authors. Journal of Viral Hepatitis Published by John Wiley & Sons Ltd.

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