Affordable Access

Hepatitis B vaccination and first central nervous system demyelinating events: reanalysis of a case-control study using the self-controlled case series method.

Authors
  • Hocine, M N
  • Farrington, C P
  • Touzé, E
  • Whitaker, H J
  • Fourrier, A
  • Moreau, T
  • Tubert-Bitter, P
Type
Published Article
Journal
Vaccine
Publisher
Elsevier
Publication Date
Aug 01, 2007
Volume
25
Issue
31
Pages
5938–5943
Identifiers
PMID: 17597263
Source
Medline
License
Unknown

Abstract

The hypothesis that hepatitis B vaccination is a risk factor for multiple sclerosis has been discussed at length. The data from an earlier case-control study were reanalyzed using the self-controlled case series method. Using the matched cases from the case-control study, we found a relative incidence of 1.68, 95% CI (0.77-3.68) for the 0-60-day post-vaccination risk period; this compares to an odds ratio of 1.8, 95% CI (0.7-4.6). When an additional 53 unmatched cases not used in the case-control study were included, the relative incidence was 1.35, 95% CI (0.66-2.79). Our results throw further light on the methodological aspects of the case series method. We recommend that, when case-control studies of vaccination and adverse events are planned, case series analyses based on the cases are also undertaken when appropriate.

Report this publication

Statistics

Seen <100 times