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Hepatic stellate cells: role in microcirculation and pathophysiology of portal hypertension.

Authors
  • Reynaert, H
  • Thompson, M G
  • Thomas, T
  • Geerts, A
Type
Published Article
Journal
Gut
Publication Date
Apr 01, 2002
Volume
50
Issue
4
Pages
571–581
Identifiers
PMID: 11889082
Source
Medline
License
Unknown

Abstract

Accumulating evidence suggests that stellate cells are involved in the regulation of the liver microcirculation and portal hypertension. Activated hepatic stellate cells have the necessary machinery to contract or relax in response to a number of vasoactive substances. Because stellate cells play a role in both fibrosis and portal hypertension, they are currently regarded as therapeutic targets to prevent and treat the complications of chronic liver disease.

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